Similar to "spider man dat hoe" {When you are fucking a hoe and you pull out, cum in your hand and fling it in her face...(like web shooting.)} except this is typically accomplished at a Frat party and instead of flinging the fluid at a girl, you immediately leave the room and the first person you see back in the party is your victim.
Spider-Man Disease is a disease in which someone has hallucinations where they believe that they are something more than human, often believing that they have superpowers. It is named after the famous superhero that people later figured out was hallucinating.
Used to describe when one is so obsessed with the character Spider-Man, they believe they are they are him.
Many fans may experience this, those whose suffer from this commonly say “I am Spider-Man” daily.