When someone is shot out it means they are permanently mentally fried from doing too many drugs.
Damn.. I miss the old Cassie.. she’s so shot out now she can’t even hold a normal conversation..
by littleforestpeach January 11, 2020
"Out of it" or brain addled from heavy drug consumption. Referring to heroin it literally means "shot out" of a person's mind.
Don't trust that guy's memory, he's shot out.
by addictmentality May 21, 2015
Lemme give a Big Shot Out to All my Niggas in the Bay...
by BarackPrez June 22, 2009
When someone does something stupid, crazy or careless.
Yo, Jimmy's drunk as shit running in the street with no shirt on. "He's Shot Out!
by Moe120 June 24, 2011
meaning messed up, retarded, and/or really bad situation
That's really shot out of Kate to steal her mom's money.

How many beers did you have? You are acting really shot out?

It's shot out what the cops are doing to Kate.
by Kimmydukes June 24, 2004
1: Crazy as in not completely mentally stable
2: Crazy as in Funny, humorous
1) You ever seen that movie Fatal Attraction? Glenn Close character is Shot-out
2) You catch that comedy show Dave Chappelle put on, dude is funny is hell. He is shot-out
by KBoogie00 December 21, 2011