An abbreviation of the Latin phrase, "For Shegro, My Negro."

Although modern linguists are unclear on the definition of the word 'Shegro', it is widely believed that it is related to the worship of the Roman Goddess Goddamnatsonehugebitchia. Certain daily activities were thought to cause the goddess to increase further in size; therefore, these activities were conducted 'for shegro.'
"Yo, you wanna go to the liquor store for a fifth of cat piss?"
"Fo' shizzle my nizzle!"

(Or, from the ancient Latin)

"Come hither, O Dumbassitus Putridus! Let us away to the market of bottled lusciousness!"
"For shegro, my negro!"
by Hellzapoppin' August 4, 2015
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To say something is definite. For sure my nigga.
1 guy: You goin' to that club tonight G?
2 guy: Fa shizzle my nizzle, I'll be hittin that spot round 11.
by Dyme_Piece April 15, 2006
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1. A polite and well meaning colloquialism used to express agreement with a cohort. (This phrase entered american vernacular when famed celebrity/artist/rapper/pornographer/movie star Snoop Dogg started using it and other words containing the suffix "izzle" or "izzy.")

2. To aquiesce to or agree with a proposition or idea offered by an affable peer.
My Boy D-Bo axed me if I was going to the game tonight... I said "Fo' Shizzle my nizzle" in the pitch of a tenor.
by Barry February 12, 2004
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Fo shizzle my nizzle translates to For sure my nigger, which translates to "Ok" in white language.
Steve: Hey you wanna go grab some KFC?
Marquis: Fo shizzle my nizzle!
Steve: I'm no nigger!
by Adam! At The Disco December 21, 2005
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Meaning:
1. affirmative; For sure, ma nigga

not necessarily in any racial context.
From a branch of urban (American) slang which adds 'izz' or varients of (ie izzle/izzo) to words to create a more rhyme like 'melody' to sentences.
kid 1: "It's late, I'm heading back to the hizzous... you stayin?"

kid 2: "fo' shizzle my nizzle"
by theJudge August 9, 2003
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