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Origin: Internet / Instant Messaging

Variation of the word "SUP". Meaning "Whats Up?"

Typing fast and frequent mispellings lead to this more lively version of "SUP"
Bob: Spu!
John: Hey!
by Grizzly October 06, 2004
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2
The term used to describe the short bus special-ed students are aboard
Jim: Hey look Joe its a Spus! HAHAHAH!
Joe: HAHAHA omg
via giphy
by Urbanworddefinitions April 06, 2017
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3
Short for “Sound Processing Unit” – sound card.
I just bought my new Creative SPU and mounted it in my PC.
by Faalagorn February 15, 2008
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4
the emission of jizz, cum or sperm; to emit an organic fluid known as semen that usually contains spermatozoa; The process of discharge called ejaculation.
I'm gonna spu my load all over that hottie.
by candygirl69 October 20, 2010
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