Skip to main content
A 'rufie' is what is known as a date rape drug. The real name of the drug(s) are Gamma Hydroxy Butyrate (GHB) and Rohypnol, which are central nervous system depressants. Because they are often colorless, tasteless, and odorless, they can be added to beverages, ingested unknowingly and used to aid drug-assisted assault ("date rape"). It is illegal to manufacture or distribute these substances for human consumption in the USA.

Gamma Hydroxy Butyrate (GHB), is a central nervous system depressant which is abused for its euphoric, sedative, and anabolic (body-building) effects. Because very small amounts of GHB are found in the human body, GHB is often billed as a natural supplement. It was widely available over-the-counter in health food stores during the 1980s, until 1992 when it was made illegal in the USA.

Rohypnol, a trade name for Flunitrazepam, belongs to a class of drugs known as benzodiazepines — the same drug family as Valium, Halcyon, and Xanax. Rohypnol is significantly stronger than the other drugs in this family. Rohypnol is sold in both Europe and Latin America as a sleep aid, but is illegal in the USA.

GHB is also known as easy lay, G, Georgia Home Boy, gamma-oh, liquid ecstasy, liquid E, liquid X (Note: GHB is not Ecstasy), GBH or Grievous Bodily Harm, Organic Quaalude, scoop.

GBL and BD, are substitutes for GHB. Street or slang names include blue nitro, firewater, invigorate, revivarant, renewtrient, revitalize Plus, somato pro, thunder nectar, and verv.

Rohypnol is also known as circles, the date rape drug, the forget pill, La Rocha, Mexican valium, R-2, rib, roachies, roofies, roofenol, rophies, roche (pronounced roe-shay), and rope.

GHB can be produced as a clear liquid (which has a salty taste but no smell), a white powder, or a tablet or capsule. It is most commonly used as a liquid - which is packaged in a small, clear, plastic bottle - and taken orally by the capful. Powder use is on the rise — typically dissolved in a beverage.

Rohypnol comes as a pill, in one and two milligram doses that is taken orally or dissolved in liquid. The tablets are often white with a line across one side, and a number "1" or "2" inside a circle and the name 'Roche.' It is frequently used in combination with alcohol, and sometimes with other drugs such as marijuana, cocaine, and heroin (to either accentuate the 'high' or help the user 'come down' from these drugs).

Both GHB and Rohypnol are inexpensive, which has made them increasingly popular with younger users.

The effects of GHB and Rohypnol follow a similar pattern. GHB takes effect within 10-20 minutes, but doesn't peak for almost an hour. Rohypnol begins to take effect within a half-hour, but does not peak for almost two hours. Both drugs initially cause a feeling of intoxication similar to alcohol (the user feels relaxed, sociable, and uninhibited), followed by a feeling of drowsiness. The effects can last from four to 24 hours. Higher doses can lead to seizures or coma. Combining use with other drugs such as alcohol can result in nausea and breathing difficulties. GHB and two similar substances, gamma butyrolactone (GBL) and 1,4 butanediol (BD) have been linked to poisonings, overdoses, date rapes, and deaths.

The long-term effects of GHB use are not known. However, since it is made from industrial chemicals, there is a risk of severe burns to the mouth, throat, and stomach from GHB that has been improperly produced. GHB may produce withdrawal effects among users coming down from the drugs effects, including insomnia, anxiety, tremors, and sweating.

Rohypnol is both physically and psychologically addictive. Withdrawal symptoms peak three to five days after use, and include extreme anxiety, muscle pain, headache, hallucinations, and seizures. Some withdrawal symptoms, including cardiovascular collapse, can be fatal.

Both GHB and Rohypnol present a serious overdose threat. Since they are depressants, both drugs can be fatal when mixed with alcohol. GHB is especially dangerous because its peak effect is delayed and users often take another dose thinking they haven't taken enough (and GHB can be fatal on its own). GHB is also risky because the strength can vary by batch. Symptoms of overdose can include intense drowsiness, unconsciousness, coma, muscle spasms, disorientation, vomiting, and slowed or stopped breathing. Fatalities usually occur from respiratory failure.

Both GHB and Rohypnol have a reputation as date rape drugs. These drugs are easily slipped into someone's drink (GHB is usually a liquid, and Rohypnol dissolves quickly), making the victim easily persuaded and physically weak, or entirely unconscious, leaving them vulnerable to rape, assault, or burglary. Rohypnol is especially dangerous because it causes black-outs, so the victim may have no memory of what happened to him or her.
"Jane was slipped a rufie last night. She's at the police station right now completing a rape kit."
Rufie by Free Hooch December 9, 2008
Words you can keep
A drug usually slipped into someone's drink. Makes the taker delerious, and usually eliminates the memory of the night after ingestion. A date rape drug.
Friend1: What the hell happened last night?
Friend2: I think someone slipped you a rufie.
Rufie by Brian Hellige April 16, 2006
Related Words
Date Rap Drug Good For Mackin Hos.
I slipped that bitch a rufie.
Rufie by Bob April 8, 2005

Rufie-Down 

The act between a male and female, in which the female lies on her back while performing oral sex and fingering the male's anal cavity simultaneously.
Did she rufie-down him last night?

Rufie-Colada 

A pina colada that has intentionally had rufies or any other date rape drug added to it.
The only way your going to get some action at the party tonight is if you start handing out rufie-coladas.
Rufie-Colada by jpassman June 12, 2007

rufie pack

a fanny pack full of date rape drugs. first seen on the creepy santa claus at the christmas party.
"check it out, that santa claus is wearing a fanny pack!"
"that's no fanny pack! that's a rufie pack!"
rufie pack by omgdoom December 22, 2008

rufie nap 

a nappkin like cloth covered in crushed rufie. Used on a date with one person so they can never say no to the question.
"hey jessica you have something on your nose......let me wipe it off with my napkin"
{rufie napkin}
After the man carrys the female out a man says "Dude did you see that guy rufie nap his date??"
rufie nap by THE HAM666 December 12, 2011
More from Urban Dictionary

Literally 1984 

Used in response for when someone promotes/advocates an event or idea that is perceived to support "too much" authority and/or government control.

Often used jokingly as a over-exaggeration in political talk.

Can also be used in response to a ban or mute in a forum site or online chat.
Steve: I think that the government should regulate businesses more
Bob: Literally 1984!

--User1 has been permantly banned--
User2: You cant ban my friend like that! Literally 1984!
Literally 1984 by ke1 July 7, 2021
Word of the Day on September 1, 2026

Back when I lived in upstate new york 

A meaningless, unimpressive, self-serving introduction. An indicator that the story about to be shared will be pointless and dumb.
Back when I lived in upstate new york, I also had to park on the street - on two occasions, we got enough snow, mixed with just the right plowing, that my car was lifted off the ground from so much snow being jammed underneath it.
Word of the Day on August 31, 2026
Acronym, meaning Too Long Didn't Understand
Similar to TLDR
Sister: This meeting was to discuss the rough draft of my essay, where we discussed the subsidiary questions I added in my rough draft. We also discussed the relationship between my main title and the real-life situations I chose to use in my essay. We discussed the structure of my essay as well, specifically the Math AOK section and how it relates to the contradiction of the title. This second meeting was particularly helpful in discussing the implications of my essay claims and how to apply the title across various areas of knowledge. There were many sections of the essay that could have been cut down in wordiness and the ways of knowing required further and more in-depth analysis.

Me: Woah! TLDU!
TLDU by L-Evans January 14, 2019
Word of the Day on August 30, 2026
the act of having anonymous sexual encounters with other men in public toilets.
Cottaging by greeef April 24, 2003
Word of the Day on August 29, 2026
Next