Beginning the act of substance abuse. That first sip or that first hit signals the push off from the hypothetical shore we call reality. The more fucked up you get the further out you are drifting. One doesn't know how far the current will take them out this evening or if they will even return.
"What are you doing on this fine Thursday night friend?"
"I got class till 5 then pushing off, you?"
by Brandon Knox September 29, 2005
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The act of "pushing" the plunger of a syringe. See also: shooting up.
We wanted to save the rest of our stash but Ellie insisted on pushing off right away.
by 5ar13 December 29, 2005
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To get high, particularly by shooting up heroin.

Used frequently in the movie, "Requiem for a Dream."
"Let's get something to eat."
"We should push off first."
by Mr. Ree January 25, 2006
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an exclamation from Britain meaning, "go away or get lost!"
"What a mankey git, hey push off!" said Clara to the creepy man, attempting to make offensive smalltalk to her.
by viking_on_stilts May 01, 2007
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