from the Greek "meso" meaning "middle" or "between", and "potamos" meaning "river", Mesopotamia refers to the ancient land straddling the Tigris and Euphrates, currently more or less the site of a completely artificial nation called Iraq, which was cobbled together by the Frogs and the Limies in 1919 out of a few odd Ottoman provinces.

There's a lot of oil there, but no weapons of mass destruction.
The Neocons in DC want us to piss away all our national wealth in an ill advised adventure in Mesopotamia
by succulentboi August 17, 2004
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1. Name of the ancient territory located between the Tigris and Euphrates Rivers from the Bronze Age to the Iron Age. Modern-day Iraq.

2. Where the band "The Mesopotamians" (Sargon, Hammurabi, Ashurbanipal, and Gilgamesh) ran out of gas while traveling in their Ecoline Van with only a single piece of gum, in the song "The Mesopotamians" by the real-life band "They Might Be Giants."
1. Teacher: You will have to do a 500 word report on ancient Mesopotamia.
Student: Awww....

2. "The Mesopotamish sun is beating down
And making cracks in the ground
But there's nowhere else to stand
In Mesopotamia (No one's ever seen us)
The kingdom where we secretly reign (And no one's ever heard of our band)
The land where we invisibly rule"
-Lyrics from "The Mesopotamians" by "They Might Be Giants".
by JordACE July 6, 2009
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Boyfriend: "Hey my Mesopotamia!"
Mesopotamia: "The fuck did you call me?"
by BlueXander May 25, 2023
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probably where you were born, because you're so decrepit.
you were born in Mesopotamia; Jesus thinks you're old.
by Saul315 November 22, 2022
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