MDE is a synthetic empathogen sometimes found in ecstasy tablets. It is closely related to MDMA though its effects are said to be milder and less stimulating.MDEA (also MDE), which stands for 3,4-methylenedioxy-N-ethylamphetamine, is a psychedelic hallucinogenic drug and empathogen-entactogen of the phenethylamine family. It is chemically very similar to methylenedioxymethamphetamine (MDMA), the active chemical in the drug "ecstasy". MDEA differs from MDMA in that it has one more carbon atom, and two more hydrogen atoms in the substituent on the nitrogen atom. The difference is evidenced in its name by the "ethyl" prefix, rather than the "methyl" prefix designating a single-carbon chain (see Alkanes). MDEA is sometimes sold as a substitute for ecstasy on the black market. It can be prepared by reductive amination of MDP2P.

MDEA works by releasing serotonin, a neurotransmitter that affects mood and perception. It requires a slightly larger dose (100–200 mg.) than MDMA with major effects lasting typically between three and five hours.1 The subjective effects of MDEA are similar to MDMA. The euphoric "loved up" feelings associated with MDMA use are not as pronounced. The effects are also not as stimulating as MDMA, MDEA has somewhat of a stoning effect and may be responsible for rumors of heroin-laced ecstasy pills. However, MDEA does have a mildly hallucinogenic effect. This, coupled with an increase in the user's energy levels (similar to amphetamine use) had led some users to conclude that MDEA is more suitable as a nightclub drug.
I went to a party and took a pill, that bean was pure MDE.
by Bounceonthis May 10, 2007
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Massive Dick Energy, a large amount of Dick Energy
Chad: Bro i have some MDE
Josh: What?
Chad: You know broski Massive Dick Energy
by a-good-pal August 20, 2019
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When a boy gives a girl the vide he doesn’t have a small but it isn’t big either it’s just in between.

MDE - medium dick energy
Rachel -“ he gives me MDE “
Emma - “ nah I get BDE
Rachel - “ nah it’s defo not big “
by Hoeisthewaytogo January 12, 2020
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Mediocre Dick Energy. In between No dick Energy (NDE) and Big Dick Energy (BDE)
“i wouldn’t say he has BDE, but i also wouldn’t say he has NDE. So maybe he just has MDE.
by thottiandra July 8, 2019
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MDE is a complete lack of confidence and zest due to the fact that one is packing a small gun. Like conceal and carry, but for a baby. #babycock
This girl (siphoe) said she wanted a Hot Big Ben, but unfortunately I am packing Mediocre Dick Energy (MDE)
by British Gal 1973 January 20, 2021
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Acronym for Mandatory Drinking Event

The realization that you will be hungover for the next three weekends in a row. Knowing at some point you will declare 'I'm never drinking again' only to attend yet another MDE soon after.
We've got Alumni Weekend, the Concert, the Wedding; I'm so screwed, they are all MDEs!
by BTA-SC June 1, 2022
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