A jojo reference is basically just everything that happent in jojo or just the sligtest resemblense to jojo
Gary: Hey! are you watching jojo?!
Harry: Yes why?
Gary: I HATE JOJO!
Harry: Sorry to tell you but thats a jojo reference! HA!
Harry: Yes why?
Gary: I HATE JOJO!
Harry: Sorry to tell you but thats a jojo reference! HA!
by Cheese.Man August 24, 2020

If you don't know the anime Jojo bizarre adventure watch it and then you realize alot of things are related to it
by Another homo sapien August 13, 2022

joe: yea i really am enjoying this resturant
unfunny fuckface retard: Is tHaT a JOjo RefErenCe???!!!
unfunny fuckface retard: Is tHaT a JOjo RefErenCe???!!!
by Kyroz March 15, 2022

A reference to Hirohiko Araki's long running manga (and anime) series Jojo's Bizarre Adventure. Usually pertaining to things simular to or referencing Jojo's Bizarre Adventure themes such as floating or exploding Kanji, posing that covers the face and aesthetic of both the show and manga.
Hey Bob was posing at the business meeting today with his hands and hips. Was that his arthritis or a jojo reference?
by HentaiExpert August 30, 2017

Increasingly used on the internet, the phrase "Is that a JoJo reference?!" refers to the anime JoJo's Bizzare Adventure. Since the anime is used in a lot of memes, when people spot something related to JoJo in a meme they tend to ask if it is a JoJo reference.
MEME: -Is a "to be continued meme", or says the word "NANI?!"-
Meme connoisseur: "Is that a JoJo reference?!!"
Meme connoisseur: "Is that a JoJo reference?!!"
by supersonicsammyfan fan September 13, 2019

by Random homo sapien August 10, 2019

This phrase is usually said when a person or group makes a comment or question that refers to a element from jojo's bizarre adventure.
by God of the defs June 21, 2020
