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ISF is Instant Skullf***, one of the best competitive Left4Dead teams in PC Gaming. They've performed in Newegg tournaments, Alienware, and gXl. Ranked in the top ten of Left4Dead teams in competition.
ISF just pwned our faces!
by sindrix December 11, 2009
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Nov 27 Word of the Day
A stupid person; it refers to the lack of surface area on an individual's brain. The general thought is that the more surface area (wrinkles, creases, etc.) a brain has, the smarter the person is. Conversely, a person with a smooth brain (no wrinkles) has less surface area and would therefore be stupid.
That fucking smooth brain put his shirt on backwards again...

That smooth brain is dumber than a pile of shit.
by Tip Tank May 14, 2011
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Bobby Chong is looking to buy 2 doughnuts for 50 cents each. The cashier lady says that will be; a dollar seven total. Bobby Chong whips out the B.C(Bank Card), swipes, punches in the pin and waits for the thumbs up for approval then 3 letters in Capitals show up on the machine; ISF. Cashier shakes her head in shame and pitty. Bobby curses and walks away for the counter doughnutless; and realizes that he will never step foot in another Tim Hortons again due to ISF...$1.07 damn. How embarrassing.
by JNL January 11, 2005
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I'm So Faded
You know what IS-F from Lexus stands for? "I'm So Faded" Brah!!!!!!
by lcr49 July 22, 2009
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icky sexual feeling; the kind of feeling you get when something makes you uncomfortable to think about or see, i.e. incest, your English teacher naked, etc.
That creepy guy who works with me looked me up and down and said, "Nice shirt." and I got total ISF.
by Jocelynnn September 23, 2005
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