synonomous to "homie".
def 1: means good friend or buddy
def 2: means someone who seems like a little slice of home, thus home slice
by home slice February 28, 2005
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Another way of saying homie, or homeboy. This is something people may say if they want to be cool, but the end up just sounding totally cringey. Using the term homeslice is not recommended. The term came around in the early 2000s.
Friend one: "Ayo homeslice! Pull up to Jessica's party tonight!" "It'll be totally lit!"
Friend two: "For sure homeslice! We gonna get so much booty!"
by ExoTiic_Taxez January 01, 2018
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A person you could trust with anything/love in a platonic way; one with whom you roll deep.
Person 1: Oh my God I hate that girl!
Person 2: Don't you dare say that, she's my homeslice.
by SS21 March 03, 2014
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