Herpeghonosyphilitis

noun ('her-peh gon nuh siff ill itis)

Broad generalization and all around insult

Combination of every STD one can acquire.

I guarantee you that slut has Herpeghonosyphilitis!

by StuRat February 20, 2008

herpegonosyphilitis

The worst of all sexually transmitted diseases. The herpes simplex virus with added genetic coding from the gonorrhea bacterium, allowing it to invade CD4+ T cells and rewrite their tRNA to code for syphilis proteins. Can only be cured by a cocktail of paracetamoxyfrusebendroneomycin and Mad Dog 20-20.

Guy 1: Dude, I think I caught herpegonosyphilitis from those 5 hookers at my party.
Guy 2: Here, have some paracetamoxyfrusebendroneomycin and a fifth of mad dog.

by Colonel Obvious February 21, 2009