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To do it. To go hard. To go balls deep. To accomplish something. To improve upon a life-skill. To party with the sickest group of skiers or snowboarders this planet has ever seen.
She's checking you out. Get after it.

You're gonna be late for your pap-smear? You better go get after it.

You didn't land that jump? You didn't get after it enough.
by Spartan Ski Club October 21, 2011
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2
(v.) 1. To exert a great deal of effort in pursuance of some worthy goal 2. To perform coitus in a manner satisfactory to both (or all) parties involved
"Get after it dude!"

"Sorry man, I can't go to the hookah bar tonight, I've got to get after it with my girlfriend."
by Dareh Meyod August 12, 2009
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3
To aggressively get fucked up. To go big. To consume party drugs and alcohol in an effort to become extremely wasted, yet still fired up enough to stay up late.
by partyboysf March 30, 2007
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