E is the face of Markiplier photoshopped on the head of Lord Farquaad which is in turn phottoshopped on Mark Zuckerberg's body. Not many people know it, but alt+num6+num9=E, that means E means 69
person 1: what does the E meme mean?
person 2: E in ascii is 69, so its 69
by UN|kn|OWN August 6, 2019
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there is no definition, just play along knobhead
E meme : ThErE is no ExamplE
by Rjoe03 January 4, 2019
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" E " is a meme that have breaked the internet currently, it's a meme with the letter " E " and a deep fryed image of Markiplier's face combined with Lord Farquaad's head.

The meaning of " E " is unknown, but we have some guesses.
1: " E " stands for " Epic " , in a sarcastic way.

2: " E " stands for " Earrape ", it has no actual meaning, just to make a meme video more funny.

3: " E " stands for " Explosion ", it means something like mindblown.
4: " E " stands for " Empty ", nothing to say.

5: " E " meme is a parody of " YEE " meme.
by Memetastics December 30, 2019
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An image of the face of the very popular Let's Player Markiplier photoshopped onto the head of Lord Farquaad from Shrek.
Guy: "What is the "E" meme?"
Other Guy: "The face of Markiplier on Lord Farquaad from Shrek."
by Memes69 August 6, 2018
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A CAPITAL LETTER, I daresay. It's known to scare british chaps into screeching incoherent british nonsense. The most notable recordings were made by Minecraft nature enthusiasts Gamechap and Bernie when they kept discovering E in it's natural habitats whether they liked it or not.
Bernie, I say, Bernie ... where are you?
-- "E" Meme
by D'Car June 27, 2022
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The funniest god damn meme to ever come upon this god forsaken land.
"Ayyy yooo, did you see that Markiplier E meme??? "
"Hell yeah bro funniest shit ever."
by yesyesdAddylikes April 14, 2020
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