D.U.

When something really lame occurs, one may exclaim "D.U."

"D.U. Look at that drunken construction worker piss on himself."

by stink-foot January 15, 2007

D.U.

fellatio; blow job; oral sex performed on a male; acronym for "drink up"

Male: Ayo shorty when Imma get that D.U.!
Female: You got me twisted! I don't put my mouth on nothin!
Originated at Lincoln University in Missouri

by izwhateva July 19, 2010