Dren in other words means strong. You can't mess with a Dren. If you a have a problem with Dren then you're fucked up.
by Madafaka12 January 10, 2017

The Farscape equivalent of the word 'shit'.
In response to people's lame "nerd backwards" definitions - If someone got called a dren, real nerds would take that as being called a shit. And real nerds are frelling awesome.
In response to people's lame "nerd backwards" definitions - If someone got called a dren, real nerds would take that as being called a shit. And real nerds are frelling awesome.
by NinjaRobot August 08, 2012

a rare species that is half man half turtlue, the creature can live up to 150 years old but its very unlikley as it feeds only on custard doughnuts and rotting flesh. this particular word is now being used as a insult.
by cmcc003 January 24, 2011

A gentler method of referring to someone (or something) that frequently exhibits characteristics commonly seen as extremely "drenny," also referred to as "extremely nerdy" or any adjectives of a similar nature. Dern is commonly used as a more abrasive variation.
Note: Dren came into use by through spelling the word nerd backwards. The word dern stemmed from a misspelling of this term.
Note: Dren came into use by through spelling the word nerd backwards. The word dern stemmed from a misspelling of this term.
by Franny D February 28, 2009

by Claudia the crazy phooning dyke February 26, 2003

/drend/ (v.) to cum so hard that you leave an area of more than two (2) feet around you soaked in DNA. "Dren" references the DNA creature (from the movie "Splice") concocted from a whole lotta DNA and left an even bigger mess.
I drenned so much whilst masturbating last night, I felt like I was committing genocide when cleaning up the mess.
by SIRFozzie July 07, 2010

Hello, my name is dren!
by Josh Martin (AbsolutelyGEEK.com) August 04, 2007
