To have a previous enjoyment of something removed by a later experience. An occurance of such grotesqueness that all previous enjoyment of the same subject matter is nullified.
I disenjoyed Spiderman 3 so much that I can't even watch the first one now.
Ugh, I totally disenjoyed sleeping with Yolanda after I found out she used to be a man.
Short-hand for the word floccinaucinihilipilification, meaning the estimation of something as valueless (encountered mainly as an example of one of the longest words in the English language).