A person that is Handsome, caring, loving, smart, charming, loves food, loves god, good at cooking, funny, entertaining, etc
Everyone: Diffie is soo charming!
by Alfiery December 24, 2019
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Means 'different' or 'difference'
"You're diffie!"
"There's no diffie..."
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sleeping pill called benadryl, nytol, etc. from its proper name "diphenhydramine".
jon: ayo mark i cant sleep over here

mark: it's okay bro just pop a diffy
by jeunclod June 12, 2021
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A slang term for clostridium difficile. Clostridium difficile has a very distinct smell.
Yo, did it smell diffy?
by ludawgg1234 March 12, 2015
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Used commonly as slang in the modern videogame League of Legends, popularized by a Twitch streamer Tarzaned and many others, when one of the players in one of 4 lanes (Botlane, Midlane, Toplane, and Jungle) hardly underperforms in the Jungle role or gets outplayed by the enemy player several times, causing the game to be lost before 20-minute margin.
Yassou: Oh no! We have Nightblue3 on our team
Sanchovies: Diffy in the Jiffy it is...
by Chrive May 29, 2020
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Mathemtician Slang:

A differemtial Equation.
Yo son, did you use the Wronskian on that mutha fuckin' ass diffy-q?
by Skandal Jack March 9, 2005
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