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Big Cheese 

Someone knowledgeable and/or of importance and high standing in an area or feild.
1. Stop addressing me as "Dr. Cox" in front of your patients. When they find out my actual name, they tend to page me with questions when they realize just exactly how inept you really are. Oh, and as an added safety measure, from now on, I'll only be responding to "Doc," "Doctor," "Ceasar," or "The Big Cheese;" and noooo, I'm _not_ joking.

2. My dad can get us on the moon within the hour. He's a big cheese at NASA...
Big Cheese by NapalmStxToKids July 24, 2008
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Big Cheese 

Person who works within 4 glass walls, mostly in charge of managing the mucky mucks.
I am the almighty big cheese. Get me my septor.
Big Cheese by gary b. February 9, 2004

Big Cheese 

He is a rapper who is rathe eat chese
"Big cheese da goat'

big cheese 

when someone gives you a big ass smile showing interest(sexually) in you or your physical appearance.
damn boy you see that girl, she just gave us the big cheese.

Big Cheese 

Yeah sure, I can sleep over, let me just ask the Big Cheese if she has a problem with it.
Big Cheese by Pantha December 28, 2008

BIG CHEESE 

BIG CHEESE by OOFcfd November 21, 2018

big cheese 

Lovers of doherty classics (look that up) like Haircut 100
big cheese by Abbot September 9, 2003