Someone knowledgeable and/or of importance and high standing in an area or feild.
1. Stop addressing me as "Dr. Cox" in front of your patients. When they find out my actual name, they tend to page me with questions when they realize just exactly how inept you really are. Oh, and as an added safety measure, from now on, I'll only be responding to "Doc," "Doctor," "Ceasar," or "The Big Cheese;" and noooo, I'm _not_ joking.

2. My dad can get us on the moon within the hour. He's a big cheese at NASA...
by NapalmStxToKids January 07, 2006
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Person who works within 4 glass walls, mostly in charge of managing the mucky mucks.
I am the almighty big cheese. Get me my septor.
by gary b. February 09, 2004
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when someone gives you a big ass smile showing interest(sexually) in you or your physical appearance.
damn boy you see that girl, she just gave us the big cheese.
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Lovers of doherty classics (look that up) like Haircut 100
by Abbot September 09, 2003
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