Nigga Balls HD comes from a video of a balding white man with a beard very exaggeratingly shouting out someone on Instagram named "big black nigga balls hd", followed by other Instagram accounts he shouts out in the same clip.
This is a meme from approximately 2018-2019, where a balding, bearded white man says "Hey, Instagram. It's shout-out time - to big, black, nigga balls HD".
The account he shouted out was part of the Hood Irony/Ironic Meme Sphere.