Used to mean "she/he/you is/are very attractive and I would very much enjoy making love to you." It is derived from "A Night at the Roxbury"
Steve: What's up? What's up? What's up? What's up? What's up?
Doug: Steve, slow down.
Steve: I can't help it man, it's hottie overload.
Doug: Just pace yourself.
Steve: Ok... What's up?... 2, 3, 4. What's up?... 2, 3, 4...
Doug: Steve, slow down.
Steve: I can't help it man, it's hottie overload.
Doug: Just pace yourself.
Steve: Ok... What's up?... 2, 3, 4. What's up?... 2, 3, 4...
by Tonberry2000 April 21, 2009
Get the What's upmug. by crakajack007 March 30, 2009
Get the Whats up.mug. ob trice is better than vanilla ice
it is not cos he is wight or his mums a dike or cos he lives in a f##ing slum its cos hes gay and takes it up the ????
it is not cos he is wight or his mums a dike or cos he lives in a f##ing slum its cos hes gay and takes it up the ????
by mazzer October 1, 2003
Get the what up?mug. That's what's good.
Person says: "Yo, I just got this/these hot new (shoes, job, CD, car, etc.) You say: "That's what's up!"
by Amber Ivy October 6, 2015
Get the That's what's upmug. 
by @CLUB_VEGAS_VIP December 23, 2011
Get the boy what upmug. by krisskidddd September 10, 2009
Get the so what up thenmug.