Also known as Trisomy 21. With 23 pairs of chromosomes, a person with Down Syndrome (i.e., a retard) has an extra 21st chromosome, causing several physical and mental defects. Usually easily recognized due to the retarded shape of their face and the clueless, happy expression on their face. These poor brain-dead sacks of sweaty garbage might be able to hold down a job as a greeter at Walmart, but this is about as high up the corporate ladder that these circus freaks typically go.
"Oh my god, did you see that dipshit window-licker trying to parallel park a shopping cart? What a down syndrome, fat fucking gay retard, fucking just dumbass stupid fucking loser. Let's kill him. I'll drown his ass, what a fucking puke piece of shit."
by Jack-the-stripper-ripper May 2, 2025
Get the Down Syndromemug. 
Get the Downmug. When you eat at panda express and after 1-2 hours you feel awful, tired, and regretful that you ate there.
by melksteak April 30, 2015
Get the panda downsmug. by bacon_creator July 10, 2025
Get the are you down to gamemug. I don't was to join your shitty newsletter you dumb motherfucker! If I wanted to join I would open the menu manually and sign up for it!
Hym "But no! You had to try and force it on me and now my phone is frozen! I can't read the article anymore and I have to close my app. Which means it's going to refresh my page! Which means I now have to go find your shitty article. Which I'm not going to do."
Iam "Hey, that's vaguely analogous to our situation. People trying to force information on us that we don't want. *Sigh* 😩 Just stop trying to force your drop-down prompt on my please. My phone sucks..."
Iam "Hey, that's vaguely analogous to our situation. People trying to force information on us that we don't want. *Sigh* 😩 Just stop trying to force your drop-down prompt on my please. My phone sucks..."
by Hym Iam June 7, 2022
Get the Drop-down promptmug. ...
by Gamerfrisk June 22, 2017
Get the FOOT DOWN!mug. When you really like a dude and you want to give him a blow job show-down. Out of all the blow-jobs your ever given, this is the cream of the crop!
by Unoriginalpseudonmy April 18, 2018
Get the Blow-Downmug.