Duff

The shake at the bottom of a bag of drugs, including the seeds and stems in a bag of weed. Commonly used to describe the shake at the bottom of a bag of crystal meth.

Jeff: Hey, let me get a ball of that fire ice. Dan: All I have left is the duff, bro.

by jlthomas110880 November 25, 2020

DUFF

Designated Ugly Fat Friend

Bob was a Duff

by prettygangswag12 March 28, 2015

Duff

DUFF - Designated Ugly Fat Friend.

Doesnt have to be fat or ugly. The weak link in the group of girls. The least attractive but it the most approachable. Use her to speak to the girl in group you want to score with.

"Damn Cindy so hot, how do i even get a chance to speak to her?"

" its simple my friend, get to know her DUFF Sarah & youre in"

by Jamattack July 17, 2016

duff

duff

Duff
Designated. Ugly. Fat. Friend
Ex. Britny is the duff in the group
Lisa and jen are hotties or the atravtive one and britney is ugly and fat compared to them
It can be guys (not alway ugly or fat) lets say they are freshmen and are like wingmen to upperclass men
*They are the ones who the girls go to ask if the jocks or alist guys in the group are single

The 2015 movie "Duff" is about a girl who is the duff in her group of friends at highschool who was unaware that she was the duff and was set oit to change it

"Duff " is not a positive thing to be called

by just a teen in 2k15 March 31, 2015

Duff

To scarf down food at a rapid pace; to eat large amounts very fast.

After I smoke, all i want to do is duff and sleep

by Fontaine June 30, 2017

Duff

Dumb, Ugly, Fat, friend

Oh my gosh she is such a duff..

by gamerpeeps500 August 23, 2021

duff

designated, ugly, fat friend

That fat bitch over there, with those other girls, is so ugly... she is such a duff.

by Liz O'nya August 15, 2016