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shane any guy named shane is a definite tweaker and you should keep at least ten feet away
“that shane guys coming i hear he’s a tweaker go to the other side of the road
tweaker by shahsnabdm June 23, 2019
Originated in Philadelphia

A female that has sex with a lot of males, possibly just to become popular of doing it because she feels like it.
If you let a boy and his friends have sex with you are considered a tweaker.
Tweaker by briight April 6, 2010
someone who just isnt right, or someone who is really good at something, ie tweaking a certain thing (or trick in bmxing)
"damn, that x-up was tweaked" "Jake is a tweaker, he nibbles those 360 nose pivot things all day"
tweaker by cellardoor4130 May 23, 2005
a man/woman who does an action that may seem strange or efed up to the people around them
hahaha look at that fukin tweaker. haha wtf is he doing?
tweaker by l)yl_A/V February 15, 2008
A person that lives in a trailer park or some sort of really shit housing that is always high on some sort of drugs. the way notice them is the really grungy, high look
Dude wtf is up with all these damn tweakers here?!?
tweaker by cereal killas May 18, 2006
Someone who likes to adjust or fine-tune things; a person who makes small changes to an existing object in order to make it better or to suit one’s preferences
Tessa is known as the Tweaker in her social circle for her knack of turning old fabrics into fashion-forward apparels.
Tweaker by fln September 23, 2013