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DUFF

It means "Designated Ugly Fat Friend". They don't have to be any of those, but that doesn't mean they don't have friends more attractive than them. The DUFF is basically the least attractive one in the group.
"She's cute, but her friends are hotter. She must be the DUFF."

"He's the youngest in the team and acts as the Gatekeeper to the rest of the team. He's a DUFF."

"That teacher is being left out from other conversations... He's a teacher DUFF."
by WattpadBlogger September 21, 2017
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Mickey duff

Mickey Duff was a well known boxing promoter whose name is now universally used as rhyming slang for marijuana.

Mickey Duff = Puff
If you want me to roll one up you’ll have to pass me my Mickey Duff.
by Loftier January 23, 2021
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duff

as in to bone a chick. to get duffed out
i duffed this sweet dude last nite yeahhh!!!
by gap slammer November 7, 2006
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duff you in

Meaning to beat some one up, to knock some ones ed off or to generally slap them about
For example I will duff you in when you get home cory

You deserve a propa duffing
by Bobz1992 February 7, 2014
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orange duffe

When you have to take a dump right after eating a huge bag of cheetos. Doritos and other orange texturized flavored chips do not count. You should only use the term when the situation is cheetos, not anything else. Spelling doesnt matter as long as its used in the correct context.
After you eat a big bag of cheetos you tell your buddy that youl just be a second, you go the bathroom and realize this might take a while that was a realy big bag of cheetos. For the first time ever youve come to the conclusion you have reached your limit and take a huge dump, the result... an orange duffe.
by od man December 9, 2007
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Duff

1. Designated Ugly Fat Friend
2. A more polite way of saying ass or butt
1. She's such a Duff
2. My Mom always tells me to get off my duff and go outside
by SauceMilliken July 31, 2017
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Fletcher Duff

A meme come to life, a Fletcher Duff is someone who personifies a number of memes often found on the internet without necessarily directly correlating with just one.
"Oh, that meme reminds me of something - i just can't put my finger on it"
"That must be a Fletcher Duff!"
by topg43 August 7, 2022
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