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That's whats up 

Used to agree with something, To say you like something, When you don't know what else to say, and when you don't know how to answer a text.
-I'll be there later.
-That's whats up.

-So, I'm bored.
-That's whats up.

-Wanna get burritos?
-That's whats up!!
That's whats up by I'mwhatsup(: February 11, 2010

Das whats up 

This means is you want to say whats up to my hommie

I'll see whats up

-A phrase used to politely and indirectly refuse a lame or unwanted invitation given by a friend or stranger without totally blowing them off in their face or over the phone.
FRIEND: "Hey the guys and I are going to get a poker game going tonight, $5 buy in, are you gamed?"
YOU: "Oh really? dude that sounds legit, I'LL SEE WHATS UP because im kinda tired."
I'll see whats up by Frank steezey November 21, 2010

Thats Whats Up?

Girl: I think we better off friends...
Guy: Thatz Whats Up?

that's whats up good lookin out 

1. an expression of approval and thanks for a good deed, OR, 2. can be used in sarcasm to show disinterest in someone's actions or feelings
1. Miss Utility: "I'm not wearing any panties."
Tito: "That's whats up good lookin out!"
or
Danny: "I got laid off today. I need to look for a new job."
Tito: "That's whats up good lookin out?

knows whats up 

A descriptive measure of a woman's predisposition to engage in sexual activities.

AKA: Down to Fuck, Puts Out, Down with the D
Person A: Hey, you that chick over there?
Person B: Yeah, I bet she knows whats up.
knows whats up by Bed Knight October 3, 2009