For ones pancreous to explode or nearly do so. Duffing is extremely painful and will require immediate medical attention to avoid a mild case of death.
1. Oh my god! I think my pancreas is duffing!
2. Man, you better slow down on the drinking, you don't want your pancreas to duff..
2. Man, you better slow down on the drinking, you don't want your pancreas to duff..
by ailsaizzy March 14, 2009
A polite way of saying "Gay". Named after the Hillary Duff Commercial in which she states that saying "Gay" is wrong.
by dramageeek September 16, 2009
"This girl I destroyed last night was so hot, I swear my dick was pulling seven or eight duffs, bro."
by Pip3s November 03, 2009
Duff is a sweet desert or pudding eaten after the main meal.
It is never a savory meal like post-scran-scran, and is not eaten before a meal like pre-scran-duff.
It is never a savory meal like post-scran-scran, and is not eaten before a meal like pre-scran-duff.
by Napa Ben April 15, 2011
by zeee! January 07, 2009