An indivisual, usually female, who will give sex in return for crack cocaine. Can be used to describe someone with a desparate immediate need for drugs.
Also- a bedraggled looking person, usually female.
Second Life reference. "Prims" are the building blocks that much of SL is made of. If you wanna build, have a house or a chair, it all takes prims. A prim whore is a SL avatar that makes excessive use of prims - hopefully to maximum effect - in creating sommat.
Hannibal made an awesome house, but man, that guy is a prim whore!