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A derogatory term for someone who uses a wheelchair.

It originates from the true final mission of Grand Theft Auto V (Deathwish/The Third Way). After escaping the ambush at the foundry, Franklin calls Lester. When he asks if "The other one" (Trevor) is alright, he angrily calls Lester "Wheels."
Franklin: "Listen, I got you on speakerphone Lester."

Lester: "Oh. Did Mike make it?"

Michael: "Yeah, I'm here."

Lester: "And the other one?"

Trevor: "I'll see you put in the ground, wheels!"

Lester: "Uh-huh."
Wheels by Ubeenbamboozledson August 12, 2021
Someone who is a harbringer of death, distruction, and chaos. Schizophrenic sociopath who believes that skinwalkers are real and that they are impersonating some of his closest friends. Called Wheels because they for whatever reason can't use their legs and need to use a wheelchair.
Friend: Oi Wheels want to go to Cap C's?

Person who is dictated a "Wheels": Your not real.
Wheels by RollinWheels November 29, 2021
Hey Wheels”

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Wheels by Mysteryman965 April 6, 2022
"nice new wheels you got there sonny" - lovely new footwear
wheels by east london mandem March 20, 2023
A vehicle that has wheels.
Hey bro, you got wheels? I need a ride to the hood.
Wheels by Fart_A_La_Cart March 26, 2023