When someone is referred to as "Piss pilled", it means that they're generally bitter, resentful, and often angry/upset at/towards others for no reason, or an irrational reason. They are called "Piss pilled" as a take on the 1999 film The Matrix, in which there is an option for the protagonist to take the red or blue pill, each with a different consequence. In recent years, red and blue pills have garnered more attention and relevance in popular Internet culture, as they have gained deeper meanings, and more pills have been made up. Too long didn't read, taking the Piss pill means that you have chosen to live a life of "pissful ignorance," or a life where you are always pissed off and everything sucks for you.
Person 1: "Why's that guy such an a-hole? I didn't even do anything and he flipped me off and told me to go f myself!"
Person 2: "Ah don't mind Brian. He's Piss pilled. It's nothing personal he's just a jerk to everyone."
Person 2: "Ah don't mind Brian. He's Piss pilled. It's nothing personal he's just a jerk to everyone."
by Suckmytoes_77 November 14, 2022

by Arch Crippledick February 3, 2009

by michaelh_66 June 10, 2008

by Medicine Man Dusty October 28, 2010

Noun: Piss Comet (pɪs-kɒmɪt)
When the Urine from the international space station is released into space and travels to a very specific distance from the sun causing particles to be released into a vapor tail.
When the Urine from the international space station is released into space and travels to a very specific distance from the sun causing particles to be released into a vapor tail.
by Human Overth June 18, 2011

by fiend420 November 28, 2009

by Blkdaimond May 31, 2011
