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Do you know what that means? 

Something said when something obvious is implied.
Bob: I dont have to go to work today.
Dave: Do you know what that means?
Bob: What?
Dave: Minecraft time obviously.

You know what that means, FISH 

This is what you say when you are or become a retard. or it is a dumb joke.
You me, gas station. what are we getting for dinner? sushi of course! uh oh there was a ruffe in our gas station sushi. we blackout and wake up in a sewer, we're surrounded by fish. horny fish. You know what that means, FISH orgy. the stench drives in a bear, what do we do? we're gonna fight it. bear fight, bear handed, bear naked? oh yes please. we befriend the bear after we beat it in a brawl. then we ride it into a chucky cheese. dance, dance revolution. revolution? overthrow the government, uuuh I think so. next thing you know, I'm reincarnated as Jesus Christ, then I turn into a jet, fly into the sun, blackout again, wake up, do a bump, white out which I didn't know you could do. then I smoked a joint, greened out, then I turned into the sun, uh oh looks like the meth is kicking in, uuubgghhhugghhuuaaahhhhaahhhhAAAHHHHHHHH!!!!!

you know what that means 

when you're just there minding your own business and then you hear the following words:
"You know what that means"
FISH.

Origin: YOU, ME, GAS STATION on YouTube

You know what that means... 

You know what that means

You know the sauce that goes on it!

A variant of "you know the score"; that is, an acknowledgement that one is aware of a meaning or perception beyond that which is immediately discernable.
"...and then with regard to these new upcharges that they claim are for a good cause—well, you know the sauce that goes on it!"