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Brain Dead Motherfucker 

An absolute Dolt. Someone who doesn't know their ass from a hole in the ground.
Man, you're one Brain Dead Motherfucker for doing that.

Real motherfucker 

Real motherfucker, someone who always commits to whatever they are doing.
For example, yo did you see Steve knock that guy out who checked out his girls ass? He's a real motherfucker

Mount Motherfucker

Known primarily among Marines undergoing training at the School of Infantry at Camp Pendleton, California as the least desirable place to hump a pack. Tops off at "Recon Ridge". Named as such because when you are going up, your thoughts consist of little more than "motherfucker..."
PFC. Smith: Fuuuck, we're doing what for PT today?
PVT. Johnson: A pack run up Mount Motherfucker.
Mount Motherfucker by usmcvegas January 9, 2010

worthless motherfucker 

To be completely without worth, and a motherfucker at the same time.
Those guys sure are a bunch of worthless motherfuckers!

mushroom-cloud-laying motherfucker 

Phrase first used by Samuel L. Jackson in the greatest movie of all time, "Pulp Fiction".

Translates to "uber-badass from hell".
"Well, I'm one mushroom-cloud-laying motherfucker, motherfucker!"

motherfudder 

A really annoying person expressing FUD (fear, uncertainty, doubt) on social media over technological progress
Will was getting annoyed by Ken being a right motherfudder over his angry posts denouncing the advantages of renewable electricity
motherfudder by Limbic Candy March 18, 2020