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Little Brother 

A term used to refer to Texas University located in Austin, Texas. Specifically, it refers to t.u.’s relationship to the state’s flagship university and Big Brother, Texas A&M University. Little Brother has a history of losing football games in its brutal in conference schedule, featuring a slate against blue blood football programs such as Kansas, TCU, West Virginia, and Baylor, otherwise known as murderer’s row.
Poor Little Brother! They’re having a hard time beating Gary Patterson and TCU, I don’t know why they think it’s a good idea to follow Texas A&M to a real conference.
Little Brother by Alpha Texan September 29, 2021
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Little brother 

The most annoying force in the universe, will stop at nothing to get his way
Dang man, my little brother is so annoying even the toilet doesn’t want anything to do with him.

Little brother 

The family communist. The snitch. Always wrapped around mom’s finger. Annoying and a fuckhead
Me: Hey bros (the bois) wanna hop on my ps5?
Little brother: you mean our ps5

Little Brother 

A person that will never pay attention to your good-intentioned recommendations and annoy you for the rest of your life.
I have a Little Brother. My life is terrible now.
Little Brother by NoPlayer69 September 2, 2022

little brother syndrome 

When one person feels they have a rivalry with another far superior person. The superior person usually doesn't know about it or feel that the little brother is any kind of a threat. The little brother usually puts forth maximum effort in meaningless situations in order to get the feeling of a win over his rival.
The Baltimore Raven's fans have little brother syndrome. They think they are the Redskin's rivals.

little brother's disease 

usually the middle child in a family who is trying to show up his older sibling.
"damn Tyrone, Drew got that {little brother's disease}! Why he always gotta be up in the mix?

Little Brother Syndrome 

An ingrained fear reaction that younger siblings show towards an elder. If properly nurtured can result in reactions such as flinching when the older sibling walks past even though the younger is taller, bigger and stronger and 18+. This can also result in a defeatist attitude and outcome when in confrontations with the older sibling.
Luke was a victim of little brother syndrome. Even though he was bigger, stronger, faster and a black belt in karate he could never defeat his older brother in a tickle fight. Luke is 20 years old.