When a man is able to masturbate to a finish with both his preferred and non-preferred hands.
Shaun: Aaron hasn't gotten laid in so long that he has become ambisextrous!

Karl: yeah, that fucking chose has no game!
by Ambisextrous June 7, 2015
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Someone who is sexually talented with both of their hands.
Dude, they had to put both his hands in a cast because his girlfriend rode them so hard.

That's what he gets for being ambisextrous
by HessTheThird June 23, 2012
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The status of having both male and female reproductive organs. An adjective describing a hermaphrodite.

Example:
John: He wanna go play a game?
Pat: No. I can't right now.
John: Why?
Pat: I have to go see my doctor about my baby.
John: But you're...
Pat: Ambisextrous? Yes. I am.
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by P.J. Fizzybottom March 10, 2011
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-predominantly refers to male on male intercourse, in which a male is both a "top" and a "bottom".

-usually there are men who are labeled "tops" and those "bottoms" in relationships. this definition is for those that are both.
A: "Hey, is Nate a top or bottom when you have sex?"

B: "He does top and bottom."

A: "What?"

B: "Nate is ambisextrous."
by Sushi Guy February 27, 2013
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