by bkv2 April 5, 2013

To be in a dominating position where one has total or a large share of control over an industry, business, enterprise or most often a drug spot.
1)
Chump: Yo look at that Escalade on 22s, that must be the cash money millionaires
Lil Nigga: Nah that's poppi, he runs shit down on 25th son
2)
"You think this is a joke motherfucker? I RUN shit, not you. The game is MINE! (shoots competition in the face)"
Chump: Yo look at that Escalade on 22s, that must be the cash money millionaires
Lil Nigga: Nah that's poppi, he runs shit down on 25th son
2)
"You think this is a joke motherfucker? I RUN shit, not you. The game is MINE! (shoots competition in the face)"
by wza August 31, 2005

Crushing an apple on your own head to intimidate an upper classman.
Ex: "Oh my god do you see Joey? He is totally running shit!"
Ex: "Oh my god do you see Joey? He is totally running shit!"
by JoeyWarren123 January 2, 2012

usually happens while walking around a mall, school, or house. starts with a walking fart, then quickly turns to the running shits. these are something not for the weak at stomach, however stomach flu can make them much worse. sometimes referred to as the trots, or explosive diarreah.
omg me and charles were walking around the mall the other day, he got the walking farts and then suddenly he had the running shits.
by sweetontweety7777 April 17, 2009

when someone is shooting at you or your girlfriend has pms. either way your pretty much totally fucked.
by Im totally hyper November 3, 2007

When you go into a store that offers their restrooms to paying customers only but you sneak in a deuce and a piss and evacuate the premises immediately before the cashier/manager notices your shit and run.
I stumbled into a convenience store that had a “Customers Only” sign on the bathroom door but I didn’t have a penny to pay but had to make a large deposit so I committed a “shit and run”
by Vic Ferrari May 27, 2020

jamie: "hey wanna chat?"
josh: "no my battery is at fucking 2% my device is gonna fucking die shit im gonna run out of battery"
jamie: "im actually osama bin laden back from death and my hiding spot is in your mom"
josh: "no my battery is at fucking 2% my device is gonna fucking die shit im gonna run out of battery"
jamie: "im actually osama bin laden back from death and my hiding spot is in your mom"
by grpo January 30, 2025
