Crazy, or insane.
But is often said to mean very fucked up on drugs.
"Is that dude loco, or what man?
"Shit man! I'm fucken Lohhhcohhhhhh right now!"
by Diego July 18, 2003
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a word derived from spanish origins meaning: crazy
Yo, look at that person right there, running across the street, she's being such a loco right now
by edgymofo December 12, 2021
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plum crazy, out of your mind, wild beyond all control, having eaten of loco weed
you're plum loco to date that chick, man; her dad's the Man
by Catherine Dunn July 31, 2008
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when two lines of people are close together and somebody runs through and everyone in the two lines severly punches the runner. practiced in team sports as a form of punishment. extremly painful.
coach: how can you miss thet penalty kick...you have a loco.

player: NOO!! not a loco please have mercy!!
by nigger2546 November 5, 2008
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A Washington D.C. word for looking rich and fresh as though you are from Loudoun County
Man that boy is lookin LoCo in his cherry sprite.
by DCDesciple August 31, 2008
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It’s Legs Out Cocks Out LOCO.
When it’s finally warm out and females are showing off their legs again, it’s that LOCO weather.
by antizombie May 16, 2019
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