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Let’s Go Darwin 

Let’s go Darwin is a play on the phrase “Let’s go Brandon”. It is used in response to those that spout misinformation or are anti-vax, specifically for the covid vaccines.
I’m not taking that dang jab. My neighbor that is a retired nurse said everyone in the hospital has the vaccine, and they’re all dying.

Okay Bob. Don’t get the vaccine and don’t seek help when you’re sick. Let’s go Darwin.
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Let's Go Brandon

Another way of saying Fuck Joe Biden. An NBC NASCAR reporter, interviewing driver Brandon Brown, attempted to convince her television audience that the crowd's "Fuck Joe Biden" chant was actually "Let's Go Brandon.". The reporter was rightly mocked for her obvious attempt at spinning, and a meme was born.

Let's Go Brandon

An alternative way of saying Fuck Joe Biden, his voters, his supporters, and people who lean left politically in general.
Man, I can't believe this old corrupt carreer politician is trying to take away our freedoms and people are actually happy to give them away so easily, Let's go Brandon!

Let’s go Brandon 

“As you can hear the chants from the crowd, let’s go Brandon

Let's go champ! 

The favorite 3 words of Logan Paul's mentally challenged black uncle.
Logan: Hey, is that a dead guy hanging from the tree
Sharon Triggs: Let's go champ!

let's go home

that shitty last thing you say to your friend as they bleed to death in a burning building.
let's go home by BukkakeButler June 24, 2016

Let's go with that. 

An attempt to evade a question. Works on the premises that people think they already know the answer and are just looking for confirmation.
Girl A: So the reason you didn't go to prom was because your car broke down?

Girl B: Yeah, let's go with that.