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a rythm game for weebs, otakus, hikikomoris and lolicons which want their favourite loli anime opening to be played by a random stranger. Other definitions for Osu are ; cancer, aid to suicide or a reason for suicide
Man i really wanna die dude...
I know man i play osu too
Osu by TheOsuGod November 16, 2017
Related Words
World's largest community college... located in Ohio.

A.K.A. TOSU, OSCC

Dear Buckeyes - "A.K.A." stands for "also known as"... the "k" is silent.
"My pappy says that I aughter go ta college, but I can't read too good."

"You should go to THE ohio state university."
OSU by M Go Blue April 3, 2005
Oswego State University - In up sate New York on the shore of Lake Ontario
OSU, Home of the Lakers
osu by Aaron Spencer October 26, 2006
Some game where you tap triangles and hold on to big long triangles
osu! by Hayden194 January 15, 2018
There are three major OSU's out there.

OSU or tOSU = The Ohio State University
oSu = Oklahoma State University
osu = Oregon State University
The lesson learned from this is don't go to any of these OSUs.
OSU by kevin4cardinals January 4, 2005
On stage urination. When someone who is on stage performing decides to urinate right there.
I didn't know Fergie liked OSU
OSU by Amy Ger December 29, 2007