osu 

1 - Ohio State University
2 - osu!

Ohio State University is a random university in Ohio duh
osu! is a rythm game, there are 4 gamemodes, osu!, osu!mania, osu!catch, osu!mania, all of these are hard in their own way

Matt: i study at osu (ohio state university)
Nathan: i was the greatest osu player (osu!)

osu by ofrfr December 13, 2020

Osu 

a rythm game for weebs, otakus, hikikomoris and lolicons which want their favourite loli anime opening to be played by a random stranger. Other definitions for Osu are ; cancer, aid to suicide or a reason for suicide

Man i really wanna die dude...
I know man i play osu too

Osu by TheOsuGod November 16, 2017

OSU 

World's largest community college... located in Ohio.

A.K.A. TOSU, OSCC

Dear Buckeyes - "A.K.A." stands for "also known as"... the "k" is silent.

"My pappy says that I aughter go ta college, but I can't read too good."

"You should go to THE ohio state university."

OSU by M Go Blue April 3, 2005

osu 

Oswego State University - In up sate New York on the shore of Lake Ontario

OSU, Home of the Lakers

osu by Aaron Spencer October 26, 2006

osu! 

Some game where you tap triangles and hold on to big long triangles

I play osu!
- Cookiezi is fucking hot.

osu! by Hayden194 January 15, 2018

OSU 

There are three major OSU's out there.

OSU or tOSU = The Ohio State University
oSu = Oklahoma State University
osu = Oregon State University

The lesson learned from this is don't go to any of these OSUs.

OSU by kevin4cardinals January 4, 2005

OSU 

On stage urination. When someone who is on stage performing decides to urinate right there.

I didn't know Fergie liked OSU

OSU by Amy Ger December 29, 2007