Usually used in reference to general frustrations felt my a mule farmers wife. Tiredness typically. Can also refer to hunger, itchy anus and other related issues.
by Sir Jerfery Darmer Mbe December 6, 2010

Learned how to "lope my Mule out behind the barn. "lope your (my) mule" is the same thing as jacking-off,masturbating, beat your meat, spanking the monkey, jerking off, & etc.
What you been doin, Buba? Did you Lope Your Mule out behind the barn?
What you been doin, Buba? Did you Lope Your Mule out behind the barn?
I got my education out behind the barn. That is where you learned how to "lope your mule". I still go out behind to do and learn things.
by Thursty June 11, 2006

to try something which won't do you no good -- it ain't a boy or a girl so you get nothing outta doin' it. May as well jack your own hammer.
by Henry Marquez October 12, 2003

by name *someguy = ? December 20, 2008

Southern expression: To refrain from beating some one's ass.
Origin: Has something to do with Jesus and his mule.
Origin: Has something to do with Jesus and his mule.
Son: Mommy, my teacher called me a dummy.
Mom: Lawd! Somebody hold my mule!
Tom: I heard that you got fired.
Dan: Yeah, I had to hold my mule on them beeotches!
Trina: Girl! They repossessed my car!
Keshia: Hold my mule!!!
Mom: Lawd! Somebody hold my mule!
Tom: I heard that you got fired.
Dan: Yeah, I had to hold my mule on them beeotches!
Trina: Girl! They repossessed my car!
Keshia: Hold my mule!!!
by CatSuga October 10, 2006

by Terry Young February 18, 2003

by Five Mule Kart Krew January 14, 2008
