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down syndrome

a medical condition where the affected individual is missing a chromosome
why does my friend have different facial features to my other friends and me?

he has down syndrome but is still very beautiful
by georgefaxel September 23, 2020
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Yolanda Syndrome

A syndrome discovered by the upcoming artist "Yoyo Nosa" that is a life phenomenon of everything going wrong if it can. Carriers of the Yolanda syndrome often experience ungodly amounts of misfortune on a weekly basis. So much that they eventually come to terms with their misfortune and gain the power to foresee it.
My ice cream fell on a tar road before I could open my car door, I must be experiencing the Yolanda Syndrome.

Some crazy driver wrecked my car my first day on the road, this has to be the Yolanda syndrome!

Costco was giving out sample cookies but the man in front of me got the last one for the week, must be the Yolanda syndrome I've been having.
by Truedattruedat June 21, 2017
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Rosenberg Syndrome

When with a woman, or about to be with a woman, your penis shrinks so as to prevent performance

or

blowing way too early so that your girlfriend leaves you as soon as she sees it, also called Pulling a Rosenberg
Isaac: Dude I heard that guy couldn't get hard for his smoking hot girlfriend.

Shay-Shay: Ya man he's got the Rosenberg Syndrome so bad!
by Messy A May 5, 2011
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The Holden syndrome

The unfortunate medical condition of having wonkey nipples.

This can be applicable for both the male and female variaties.
Dude, that guy has wonkey nips... I can see them poking through his shirt!
Yeah, have you not heard? He suffers from the Holden syndrome. Poor guy.
by dstark March 11, 2010
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Begum Syndrome

Symptoms: Having friends one day then not having any the next day.
Unknown cause

Likely also observed with random lisps which don’t match conventional lisp pattern. I.e. one would say schtay as opposed stay.

Not to be confused with Shamima Begum syndrome which involves fleeing to Syria then wanting to return without any remorse or sympathy.
Dude 1: “Damn that girl talks funny and she’s a bit weird uno”
Dude 2: “Stop bro! She suffers from Begum syndrome”
Dude 1: “Arrrrr makes sense, of course!”
by ItsYourGirlShagufta March 14, 2019
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Down syndrome

Yo have you heard of down syndrome Hes hella trash
by Thatpnoy December 3, 2018
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Quake Syndrome

Noun; A disorder commonly found in video games which causes almost everything in the game to be gray and/or brown.
Friend 1: Dude! I f**king love Gears of War!

Friend 2: It's alright, but it has srs Quake Syndrome.
by jmerridew124 August 18, 2010
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