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PLUR Plague 

An illness or disease obtained after a rave or party involving electronic music, where the phrase PLUR is popular. It is usually due to the large amount of people and interactions that are common and encouraged at these events.
Person 1: I think I got sick from that rave on Saturday night
Person 2: It must be the PLUR Plague
PLUR Plague by TwilyXD February 26, 2010
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Lesboobonic Plague 

A short phrase that sounds funny, yet has no true meaning
Person 1: Lesboobonic Plague
Person 2: HAHAHA

Hood Plague

The Hood Plague is a sinus condition contracted by students in the third or fourth week of Fall classes after the air conditioners come on in the dorms.
"Crap, I have a paper due tomorrow but I can't think because I have the damn Hood Plague"

"Can I get out of class, I've come down with Hood Plague"
Hood Plague by Hoodlum December 9, 2012

Economical Plague 

An indie rap group composed of young teenage rappers, notably Casper/Kasper (theGhost), Unonimus, and Lotus.
Did you check out that new Economical Plague song? It was fire.

Nugget plague 

A plague of chicken nuggets that want to feed themselves to you
The nugget plague has caused many people you explode from obesity
Nugget plague by Cool bro Reid November 13, 2014

Dildonic Plague 

Disease where you constantly get slapped by dildos
Doctor: I'm sorry but your son has the Dildonic Plague
Dildonic Plague by Mr splash August 29, 2016

Irish plague 

Me to my girlfriend before we got busy for the first time: 'I have the Irish Plague'

Her in her charming New York accent: 'You asshole, I don't want to catch that'
Me: 'No, it means me prick is small'