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ur sister a mister 

If the "Your Granny and TRANNY!" get pulled out you must say "YOUR SISTER A MISTER!!" and this rude human will die of brain cancer.
Tim"You are a cunt"
Me"No you"
Tim"Ur dad has big gay"
Me"No u"
Tim"Your granny tranny"
Me"Your sister a mister"
Tim *DIES*
ur sister a mister by Gayuun May 10, 2018

Ur sister a mister 

The worse possible insult above "ur mom gay" "ur dad lesbian" "ur granny a tranny" and "ur granpap a trap"
James: lol ur mom gay
Holden: ur dad lesbian
James: ur granny a tranny
Holden: ur granpap a trap
James: well ur sister a mister
Holden: *shrivels up and dies*

Ur sister a mister 

An insult known and feared by all of mankind and even god himself... An insult so powerful and so great it could destroy life as we know it. One of the only insults more powerful than ur mom gae

Below we shall see but mortal a man attempt to use this insult against another though be warned life... may go extinct
john: Hey mike!
Mike: yeah what is it John?
John: ur mom gae
Mike: pathetic!
also mike: UR DAD LESBIAN!
John: ur brother a mother
Mike: you have forced me to use my ultimate power...
john: NO! MIKE DONT DO IT!!!!!
Mike: ur sister A Mister
(the solar system gets torn into pieces and life as we know it dies)

NOW BUT ONE MAN STANDS AND HIS NAME SHALL FOREVER BE FEARED AND WORSHIPPED!!!! A MAN SO POWERFUL GOD HIMSELF PISSED HIMSELF.

Ur Sister's a mister 

It is almost As worse as ur granny tranny, but instead the Sun moves close to Earth not the Earth closer to the sun
Jake: Hey Shawn what's up?
Shawn: Your sister's a mister!
Jake:......

Ur sister is a Mister 

Dave: Ur mom gay
Kieth: Ur sister is a mister

*alternate reality gets destroyed*

Ur sister is a mister 

The insult searched for in the depths of Volcanos, anytime this is used an alien race is wiped from existence
1: ur mom gay
2: ur dad lesbian
1: ur granny tranny
2:ur grandpap a trap
1: ur sister is a mister
*zarblorgs fuckin die*