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This is an abbreviation for Orange County. I personally have never heard of the abbreviation since they came up with that stupid TV show the O.C. I guess people think they are cool when they say O.C. instead of saying Orange County. Notable destinations are Disneyland, and Knotts Berry Farm.
Dude, lets go to the O.C. and go to Disneyland!

O.C. by RobYo April 29, 2008
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Osceola, the best place in Indiana to make crop circles!
i live in da big OC
O.C. by Mayonaise June 17, 2003
John: Is the O.C. in California?
Jane: Yes Sir.
O.C. by Bye69 April 28, 2009
A 73 year old man who hangs around 16 year old boys. (abbrevaition for old cunt)
Geoff was being such an O.C. last night, he didnt buy us a slab
O.C. by Geoff June 1, 2003
as in On Crack
used in south chicago meaning crazy or fucked up
that teacher is definitely O.C.

girl, you o.c.
o.c. by mr things September 14, 2006
Josh is O.C. to the C.O. cut off
o.c. by kenz November 26, 2003
adjective used to describe one who's over reacting and looking depressed.
At the moment, my girlfriend is all depression and emotional, she's so O.C.
O.C. by vincie May 9, 2007