The name you give to your mentally challenged friend (for they have an extra chromosome)
"Yeah I know David has autism but we're chill, he's my chromie homie"

"That special ed kid is my homie with an extra chromie"
by TheRollexWatch November 29, 2016
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When you or someone else has an extra chromosome causing them to be retarded
Bro I think Melisa from the Voice has an extra chromie
by PPSOFTBrynanna May 17, 2019
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The most powerful, super group of speeds to ever roam the world! Their quest is to rid the world of all things Gay and eViL. The Chromosomes will live on! With their Captain, The Helmet, Tourette’s, A creature known as WWW, Anyerismo, Mr.Chromtastic, Downy Boi, and The Caretaker(who is the only normal person in this stupid ass group). Together they will stop all evil and get rid of the gay(and Helseth)
Oh Shit! The Chromie Homies are here!
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The act of going around and stealing chrome or cool looking tire valve stem caps from cars around the neighborhood.
The other day, me and my homie were Chromie Hunting and we got two dice caps! Hopefully the guy didnt notice yet.
by luke4010 July 19, 2011
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the act of taking chromies (chrome valve caps) off car tires to put on your bike tires.

or just for fun.

i went scoping chromies yesterday
by XylophoniX April 2, 2007
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1.When your chromosomes have an extra homie
2. When you and your friends have an extra chromosome
by Edubb23 March 3, 2019
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