Uncle Jesse 

The act of raping a set of twins.

You see the Olsen twins, I just gave them an Uncle Jesse.

Uncle Jesse by Tanner Family September 24, 2012

Uncle Jesse 

When two men are caught rubbing their anuses together.

Uncle Jesse saw the Duke boys rubbing their anuses together down by the crick. Uncle Jesse masterbated while Danny Tanner and Joey rubbed their anuses together.

Uncle Jesse by Last_Boy_Scout November 13, 2011

Uncle Jesse 

A bearded racist from the backwoods of Georgia who guzzled Daisy's huckleberry pies like it ain't no thing. He was played by Denver Pyle, the father of John Stamos. Denver Pyle died a while ago; he died of lung cancer. It probably sucked. He was from Methune, Massachusetts

Denver Pyle? You mean Mr. Methune?

Uncle Jesse by T Dog Jenkins June 11, 2004