A combination of the words "Twitter" and "snowflake." Someone on Twitter that gets really defensive over something that's (overall) trivial. This can also apply to politics, gaming, tv shows, etc. They'd mostly throw out derogatory terms like "racist", "homophobic", "ableist", etc. usually deriving from places like Tumblr.
This person on Twitter is being a twit-flake because someone made a sarcastic joke. So they decided to call the person "racist." Then the other person came out saying it was sarcastic. The twit-flake decided to call that person "ableist" since they didn't include "/s" in the middle of their joke. Even though it was easy to identify as sarcasm even without "/s."
by TheBlankOne November 24, 2020
Get the Twit-flakemug. 
Get the Twitmug. 1. John you are a fucking Twit Whistle. Grow The Fuck up!
2. You guys are a bunch of Twit Whistles, Leave me alone!
3. My wife has been such a Twit Whistle Lately that I'm not giving her any sex!
2. You guys are a bunch of Twit Whistles, Leave me alone!
3. My wife has been such a Twit Whistle Lately that I'm not giving her any sex!
by Idisownbikesnobs June 5, 2016
Get the Twit Whistlemug. When your deputy tells you to turn left, then turn right. But you drive through a wooden roller coaster with your squad car.
by Gangly Don September 23, 2023
Get the moose twitmug. 
An individual who taunts others for doing something they have to do, when it's the taunter's fault they even had to do it to begin with.
Jordan: Hey Kyrsten, why don't you go hang out with that 70 year old you like so much?
Kyrsten: If you weren't such a twit, Jordan, and had helped me move my furniture when I asked, I wouldn't have had to ask a real man to help me!
Kyrsten: If you weren't such a twit, Jordan, and had helped me move my furniture when I asked, I wouldn't have had to ask a real man to help me!
by SickOTheSickos March 1, 2020
Get the twitmug.