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The answer to the ultimate question of Life, the Universe, and Everything 

a: What is the answer to the ultimate question of Life, the Universe, and Everything?
b:42

theory of everything 

Theory of Everything (ToE) is the point in quantum theory Level 4 where the entire data set of everything ever known to exist is resolved in a simple equation: Life = Zero or One (depending on the size of your shaft)
I was bummed out when I my wife died, but then I read about Theory of Everything in hustler magazine.

DELETE FUCKING EVERYTHING 

Basically what you do when you're in deep shit, namely when you've been or are about to be v&.
After Ricky was caught with CP on his comp, he decided to cover his tracks as best he could, which was to DELETE FUCKING EVERYTHING.

Thats on everything 

A statement that means, what I jus told u is true.
"Keesha and that nigga Kacey slid off last night!" Thats on everything! "

Family Is Everything

Person: It's for my family
Dom Toretto: Did someone say family?
Person: Dom Toretto?
Dom Toretto: Family Is Everything

make me one with everything

The above user is wrong, or is quoting some lame malapropism of the original joke.

"Make me one with everything" is the response given by a Buddhist to a hot dog vendor who asks him, "What can I make you?".

The joke is a play on words, as the oft-quoted Buddhist "motto" is to "be at one" or "be at peace" with everything natural in the world.
A Buddhist goes to a hot dog vendor and the vendor asks him "Hey buddy what can I make ya?".

"Make me one with everything" replies the Buddhist.