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Not much, actually, since said famous physicist has been deceased for nearly 70 years.
If someone jokingly asks, "What have you done 'fermi' lately??", it could mean dat he was hoping dat you could come up with some brilliant breakthrough or illuminating invention.
by QuacksO March 6, 2024
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Used to express astonishment when somebody says or does something completely out of character. The only possible explanation is that they've been replaced by an alien shape-shifter who looks exactly like them, but acts differently.

The phrase is a parody of the cliché found in old movies, when somebody returns home to find their lover gone and a stranger in their place.
Shanee: "I'm going to stay in tonight and study."
Ruthie: "Who are you, and what have you done with Shanee?"
by Yogi Bhajan February 26, 2011
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A common thing teachers say in primary school, when you upset someone or hurt someone.
It can also be used when you are TALKING WHEN THE TEACHER IS (which btw I have not done) ;)
You pull Bob’s hair.
Bob is crying like crazy.
Me: It wasn’t me!
Teacher: Say sorry NOW!!
Me: Uh, sorry Bob
Teacher: Now go sit in timeout and think about what you have done.
Reluctantly, you go and sit in the ‘special timeout chair’ that isn’t different from the rest of the blue chairs.
by Shrek is a potato March 23, 2023
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It is the presence of God in your life, not your possessions, that makes you a success—stop chasing material things and start a personal relationship with Him.
You may be financially naked, educationally unqualified, and not connected to people of influence, yet if you've faith in the power of the presence of God in your life, you can expect your nothings to turn into somethings—who you have, not what you have is what matters.
by MathPlus March 15, 2017
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It's a metaphor for asking what someone is up to or doing
Friend: i'm bored and i have nothing to do right now. What do you have your elbows in?
by cinnamonxsticks November 15, 2011
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