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Sometimes used in place of "spin up" or "start up" Many meanings.
1. The hard drive on my computer failed to run up
2. Now dont get me run up, you wont like what happens..
3. Me and my GF totally run up
run up by FinalPhoenix September 24, 2003
Let’s fight.
Run Up by GHUIAH October 29, 2018

run up a check 

To get a whole lot of money usually referring to thousands of dollars or more
We bout to run up a check!
run up a check by BoogieBrayne March 10, 2017

Run up on a nigga 

when your about to go up to someone and beat their ass
I'm about to go run up on a nigga and rock his shit
Run up on a nigga by DADDY Ak 🍇 November 28, 2016

run up on 

so then she gonna run up on me talkin about i owe her some money.
run up on by shatda shekem May 13, 2005

run up on your spot

To approach someone with the intention to bring harm. Most commonly with a shank and/or baseball bat wrapped with barbed wire.
"Run up on your spot like CJ from San Andreas!"
run up on your spot by Reg M August 4, 2006